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The endothelium, the delicate, single-cell inner lining of all blood vessels, is highly vulnerable to ROS-induced damage

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Individuals with an active or prior history of certain cancers, those who are pregnant or breastfeeding, and people with specific endocrine conditions are generally not appropriate candidates

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On the contrary, administration of dynasore (inhibitor of VEGGR2) didnt activate the pathway and blocked endothelial tube formation [3]

Johnson DE, OKeefe RA, Grandis JR